Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target
نویسنده
چکیده
Autotaxin (ATX) is an extracellular lysophospholipase D (lysoPLD) released from normal cells and cancer cells. Activity of ATX is detected in various biological fluids. The lysophosphatidic acid (LPA) is the main product of ATX. LPA acting through specific G protein-coupled receptors (LPA(1)-LPA(6)) affects immunological response, normal development, and malignant tumors' formation and progression. In this review, the impact of autotoxin on biology of melanoma cells and potential treatment is discussed.
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عنوان ژورنال:
دوره 2011 شماره
صفحات -
تاریخ انتشار 2011